Pour cette conférence, le Centre de recherche CERVO et le CINQ ont le plaisir d'accueillir M. Muhammad Saleh. M. Saleh est stagiaire post-doctoral au département de radiologie et de sciences radiologiques de John Hopkins University.
Titre de la conférence : Universal MRS sequences for single- and multi-metabolite editing
Mercredi le 15 décembre 2020
11h00 - 12h00
Centre de recherche CERVO, local F-1455
2601, chemin de la Canardière, Québec
Magnetic Resonance Spectroscopy (MRS) is a non-invasive methodology that allows the quantification of endogenous metabolites in the human body, including the inhibitory neurotransmitter GABA and redox compound glutathione (GSH) in the brain. However, due to their low concentration, measurement of GABA and GSH using conventional single-voxel MRS is difficult, and at 3T, spectral editing (MEGA-PRESS) is typically used. In this seminar, I will describe how GABA and GSH can be measured in the brain using spectral editing, including some of the limitations of the methodology. Most previously used edited MRS techniques focus on a single-voxel and are tailored for a specific metabolite (e.g., GABA, or GSH). I will then introduce a new method developed in our lab, HERMES, which allows multi-metabolite editing in one single MR examination. Finally, I will discuss recent work we have been doing, developing universal sequences across vendors, and present some of our new results.
Muhammad Saleh is a postdoctoral fellow in the Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine. Originally from the beautiful island of Zanzibar, Tanzania, Muhammad received his Ph.D. from the University of Cape Town, South Africa, involving prospective motion and magnetic field correction during GABA editing, followed by in vivo applications. As a fellow at Hopkins, he develops novel methods for measuring brain metabolites, including inhibitory neurotransmitter GABA and marker of oxidative stress glutathione (GSH), under the mentorship of Professor Edden. Recently, he standardized these methods across all four major vendors, Philips, Siemens, GE, and Canon, and disseminated to more than 20 sites nationally and internationally to study the pathophysiology of a broad range of neurological diseases. He continues to provide support to and collaborates with the researchers from different sites, ranging from acquisition to post-processing and quantification of data using the Gannet analysis package.