Georg Oeltzschner, Ph.D. - New frontiers of edited magnetic resonance spectroscopy

  • 09 May 2019


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Pour cette conférence, le CINQ a le plaisir d'accueillir M. Georg Oeltzschner. M. Oeltzschner est stagiaire postdoctoral sous la supervision du professeur Richard A.E. Edden au département de radiologie et de science radiologique Russel H. Morgan de la Johns Hopkins University, Baltimore, États-Unis.

Titre de la conférence : New frontiers of edited magnetic resonance spectroscopy.

Résumé : Dr. Georg Oeltzschner gives an introduction into spectral edited MRS, presents his most recent methodological developments, and discusses existing and future applications in neuroscience and clinical research.

Magnetic resonance spectroscopy (MRS) allows researchers to non-invasively quantify a multitude of chemical compounds in living tissue, providing a unique window onto the neurochemistry of the human brain in healthy functioning and disease. Currently, the limited spectral resolution and signal- to-noise ratio at common clinical MR field strengths (3T) requires specific, time-consuming “spectral editing” methods for the reliable detection of low-concentration metabolites. As an example, measurement of the primary inhibitory neurotransmitter, g-aminobutyric acid (GABA), typically requires a 10-min acquisition per region of interest, severely limiting the number of metabolites (and regions) that can be studied within a typical human subject MR protocol. 

A class of novel MR sequences and acquisition techniques is designed to overcome this fundamental shortcoming of spectral edited MRS at 3T. The PRIAM and SHERPA methods allow for data acquisition from two or more MRS voxels at the same time. Hadamard-encoded acquisition schemes (HERCULES, HERMES) enable simultaneous spectral editing of up to thirteen metabolites, including the neurotransmitters GABA and glutamate, the antioxidant compounds glutathione and ascorbate, the glutamatergic modulators aspartate and N-acetylaspartylglutamate, and the anaerobic marker lactate. These new multi-metabolite-multi-voxel methods are equivalent to multiple sequential single- metabolite measurements, revealing transformative potential for the kinds of in-vivo neurochemistry studies that can be conducted on common clinical MRI scanners. 

Jeudi le 9 mai 2019

Centre de recherche CERVO, salle F-1455

IUSMQ, 2601 chemin de la Canardière, Québec

13h30 - 14h30 : Conférence

15h - 16h : Café discussion avec les étudiants et stagiaires postdoctoraux

Au plaisir de vous y voir en grand nombre !

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Pour informations, contacter le coordonateur du CINQ au (418) 663-5741 poste 4547.

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