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Conférences méthodologiques et scientifiques du CINQ - Parkinson's Disease targets intrinsic brain networks

  • 08 May 2015
  • 1:30 PM - 2:45 PM
  • Centre de Recherche - Institut universitaire en santé mentale de Québec (IUSMQ) , Salle F-1455 2601 Chemin de la canardière, Québec QC G1J 2G3

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The talk will cover two recent exciting discoveries in neuroscience:


(1) the imaging of intrinsic brain networks


(2) evidence that neurodegenerative processes target these networks, which may act as conduits for the transneuronal spread of disease-causing misfolded proteins. Intrinsic brain networks consist of spatially distinct brain regions that are heavily interconnected and tend to show correlated activity (as measured by fMRI).



Second, recent evidence suggests that some neurodegenerative diseases like Alzheimer’s and Parkinson’s Disease, may involve prion-like spreading of misfolded proteins via neuronal projections. These proteins (tau, beta-amyloid, alpha-synuclein) are thought to cause further protein misfolding, and disease propagation via intrinsic brain networks.


 We will review brain imaging evidence supporting this network spread hypothesis.





Centre intégré en neuroimagerie et neurostimulation de Québec

Centre de recherche CERVO, 2601, chemin de la Canardière,       

bureau S-2119, Québec (Qc) G1J 2G3

418-663-5000 poste 8703

contact@cinq.ulaval.ca


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