Cette conférence sera animée par Mathieu DEHAES, PhD
Assistant Research Professor, Department of Radiology, Université de Montréal, Montréal, Canada
The neonatal brain is particularly vulnerable to the biological consequences of prematurity, to birth asphyxia, congenital heart disease and other metabolic disorders. Brain injury and altered or delayed brain development in the neonatal period are associated with devastating neurodevelopmental consequences such as significant cognitive, motor, language and behavioural disabilities.
It is now appreciated that hypoxic-ischemic insult impairs oxidative metabolism. With neuronal activity tightly linked to oxidative metabolism, direct measures of the cerebral metabolic rate for oxygen (CMRO2) likely provide the most direct measure of brain health.
Frequency domain near infrared spectroscopy combined with diffuse correlation spectroscopy provides a bedside quantitative index of cerebral blood flow that enables the calculation of an index of CMRO2.
In this talk, Mathieu Dehaes will shows the potential of this innovative technology to screen for brain injury, monitor evolution of injury and assess response to therapy in an effort to prevent neurodevelopmental outcome in at-risk neonates.